Rino Rappuoli has more than 40 years in the vaccines field. He was CSO at Chiron (2003-2006), Head of vaccine R&D for Novartis (2006-2015) and Chief scientist and head external R&D at GSK (2015-2022). Presently he is the scientific director of the Fondazione Biotecnopolo di Siena, the Italian Institute for Pandemic Preparedness. He is also Honorary Professor, Imperial College, London, and Senior Professor, University of Siena. He is elected member of US National Academy of Sciences (NAS), the American Institute for Medical and Biological Engineering (AIMBE) the European Molecular Biology Organization, the Royal Society of London, and President, International Union of Microbiological Societies. He has published 800 works in peer-reviewed journals. He introduced novel scientific concepts like genetic detoxification, cellular microbiology, reverse vaccinology, and pangenome. He has developed licensed vaccines among which for acellular pertussis, meningococcus C, and meningococcus B. Dr. Rappuoli is among the world scientific leaders dedicated to the sustainability of global health.