The
High Throughput Screening facility of ICGEB counts over 10 years’ experience in the development of innovative, image-based High Throughput Screening (HTS) approaches to dissect complex molecular pathways involved in human diseases.
At the core of the HTS-BSL2 facility is a fully automated platform designed to support operator-independent processes. Equipped with a collaborative robotic arm, this platform seamlessly integrates essential instruments, including a confocal microscope for HTS imaging, an existing multimodal plate reader (Envision, PerkinElmer) and an automatic incubator for multi-well plates, all vital for high-throughput experimentation. The confocal microscope within the facility boasts an array of features tailored for HTS applications. From fluorescence imaging of standard SBS-format plates to digital phase contrast for label-free imaging, this microscope offers versatility and precision. With automated objective switching, advanced fluidic systems, and a high-speed stage with exceptional positional accuracy, it enables detailed imaging and analysis of biological samples. Furthermore, the facility is complemented by a liquid handler capable of dispensing liquids accurately and efficiently into multi-well plates. With features such as peristaltic pumping, column-wise operation, and user-friendly interface controls, this instrument streamlines experimental processes while ensuring reproducibility and precision.
The facility’s layout is meticulously designed to optimize workflow and accessibility. The incubator, crucial for maintaining experimental conditions, is situated in a contiguous environment connected to other instruments. This layout ensures efficient operation while preserving ergonomic considerations for manual plate loading.
Moreover, the HTS-BSL2 facility is equipped with advanced software solutions for programming, management, monitoring, and automation of experimental processes. The user-friendly graphical interface allows for intuitive operation, eliminating the need for extensive programming skills. Additionally, the platform includes a base video monitoring system, enabling remote activity monitoring for enhanced convenience.
By integrating advanced technologies, automated workflows, and user-friendly interfaces, this facility empowers researchers to conduct large-scale experiments with unprecedented efficiency, accuracy, and reliability.
📍 The “Functional Screening Facility” is located at ICGEB laboratories in Area Science Park.
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