Microlab STAR
The Hamilton Microlab STAR is an automated liquid handling system for high accuracy, precision, and repeatability from sub-microliter to large volumes. The smooth interplay between software and mechatronics, coupled with an intuitive user interface makes the liquid handling of the Microlab STAR easy to program and less error prone.
The system configuration includes a single working arm, Modular Arm MPH, equipped with:

• 8 individual 1000 μl channels (volume range 0.5 – 1000 μl)
• 384-channel multichannel head (volume range 0.2- 50 μl with 384 tips and 1-300 μl with Rocket tips)
• iSwap robotic transport arm for integrating the plate sealer
• CO-RE gripper for transporting plates and lids on the worktop
• capacitive sensors for active liquid level recognition
• independent movement with asymmetric spreading

Operetta CLS High-Content Analysis System

Operetta CLS is a high throughput microplate imager for high-content analysis (HCA). It can acquire, analyze and manage fluorescence, brightfield and digital phase contrast images. The combination of high power LED excitation with fast, precise mechanics and one large format sCMOS camera enables fast imaging. Controlled by Harmony software it offers a seamless workflow, for reliable discrimination of phenotypes even in complex cellular models.

• Fluorescence imaging of standard 96- and 384-well SBS-format plates, with underplate acquisition. It also allows acquisition of images from multi-well plates of other formats (6, 12, 24, 48 wells)
• Widefield and spinning-disk fluorescent imaging
• Digital-phase contrast imaging modes for label-free imaging
• Air objectives:
  • 20x NA 0.4 mm WD 8.28 mm
  • 5x NA 0.16 mm WD 12.1 mm
  • 10x NA 0.3 mm WD 5.2 mm
  • 20x NA 0.8 mm WD 0.55 mm
• Water objectives:
  • 20x NA 1 mm WD 1.7 mm
  • 40x NA 1.1 mm WD 0.62 mm
  • 63x NA 1.15 mm WD 0.6 mm
• 16-bit, 4.7 megapixel (2160x2160) sCMOS camera with a pixel size of 6.5 x 6.5 μm², enabling high-resolution image capture, high frame rate (up to 105 fps) and wide field of view
• High-power LED light source for optimum excitation of the sample equipped with excitation filters:
  • 365 nm
  • 475 nm
  • 550 nm
  • 630 nm
  • 440 nm
  • 510 nm
  • 580 nm
  • 660 nm
• Emission filters:
  • 430-500 nm
  • 500-550 nm
  • 570-650 nm
  • 655-760 nm
  • 570-620 nm
  • 665-705 nm
  • 460-515 nm
  • 600-640 nm
  • 585-640 nm
• Software control of both temperature (range 37 °C - 42°C +/- 1°C) and CO2 concentration (range 1-10% +/- 0.5%) for live-cell imaging

The system is also equipped with:

• Automated robotic plate loading plate::handler Flex
• Cytomat 2 C-LIN automated incubator
• 3 random access plate racks with 21 positions for SBS plates for a total of 63 available positions
• Barcode reader
• Multidrop reagent dispenser Multidrop Combi
• Microplate sealer Azenta