The facility offers orthogonal biophysical methodologies to allow a consistent view of target-ligand binding events. While naturally included in hit-to-lead pipeline, the facility will be of use when investigating the molecular basis of pathogenesis. The facility analyzes targets and ligands of very different molecular weights and affinities also in very concentrations (up to femtomoles).
Thermodynamics, kinetics, and hydrodynamics can be explored with the facility, in a medium to high throughput perspective with low-volume and low-concentration samples. The lab includes also a HPLC-MS system for analytical and preparative purposes.
📍 The “Target-ligand interaction” facility is located at CNR-IC and Elettra Sincrotrone Trieste laboratories in Area Science Park.
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